| Thermo-Optoplasmonic Single-Molecule Sensing on Optical Microcavities | |
| Toropov, Nikita A.1,2,3; Houghton, Matthew C.1,4; Yu, Deshui5; Vollmer, Frank1 | |
| 2024-06-26 | |
| 发表期刊 | ACS NANO
 |
| ISSN | 1936-0851 |
| 页码 | 13 |
| 摘要 | Whispering-gallery-mode (WGM) resonators are powerful instruments for single-molecule sensing in biological and biochemical investigations. WGM sensors leveraged by plasmonic nanostructures, known as optoplasmonic sensors, provide sensitivity down to single atomic ions. In this article, we describe that the response of optoplasmonic sensors upon the attachment of single protein molecules strongly depends on the intensity of WGM. At low intensity, protein binding causes red shifts of WGM resonance wavelengths, known as the reactive sensing mechanism. By contrast, blue shifts are obtained at high intensities, which we explain as thermo-optoplasmonic (TOP) sensing, where molecules transform absorbed WGM radiation into heat. To support our conclusions, we experimentally investigated seven molecules and complexes; we observed blue shifts for dye molecules, amino acids, and anomalous absorption of enzymes in the near-infrared spectral region. As an example of an application, we propose a physical model of TOP sensing that can be used for the development of single-molecule absorption spectrometers. |
| 关键词 | microresonator plasmon protein tryptophan sensor absorption |
| 资助者 | UKRI Engineering and Physical Sciences Research Council ; UKRI Engineering and Physical Sciences Research Council ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Engineering and Physical Sciences Research Council ; UKRI Engineering and Physical Sciences Research Council ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Engineering and Physical Sciences Research Council ; UKRI Engineering and Physical Sciences Research Council ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Engineering and Physical Sciences Research Council ; UKRI Engineering and Physical Sciences Research Council ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership |
| DOI | 10.1021/acsnano.4c00877 |
| 关键词[WOS] | WHISPERING-GALLERY MODES ; LABEL-FREE ; PROTEIN ; ABSORPTION ; SHIFT |
| 语种 | 英语 |
| 资助项目 | UKRI Engineering and Physical Sciences Research Council[EP/T002875/1] ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership[BB/T008741/1] |
| 资助者 | UKRI Engineering and Physical Sciences Research Council ; UKRI Engineering and Physical Sciences Research Council ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Engineering and Physical Sciences Research Council ; UKRI Engineering and Physical Sciences Research Council ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Engineering and Physical Sciences Research Council ; UKRI Engineering and Physical Sciences Research Council ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Engineering and Physical Sciences Research Council ; UKRI Engineering and Physical Sciences Research Council ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| WOS记录号 | WOS:001255677400001 |
| 出版者 | AMER CHEMICAL SOC |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://210.72.145.45/handle/361003/14498 |
| 专题 | 量子频标研究室 |
| 通讯作者 | Vollmer, Frank |
| 作者单位 | 1.Univ Exeter, Dept Phys & Astron, Exeter EX4 4QD, England 2.Univ Southampton, Optoelect Res Ctr, Southampton SO17 1BJ, England 3.Harbin Engn Univ, Qingdao Innovat & Dev Ctr, Qingdao 266000, Shandong, Peoples R China 4.Univ Bath, Dept Life Sci, Bath BA2 7AX, England 5.Chinese Acad Sci, Natl Time Serv Ctr, Xian 710600, Peoples R China |
| 推荐引用方式 GB/T 7714 | Toropov, Nikita A.,Houghton, Matthew C.,Yu, Deshui,et al. Thermo-Optoplasmonic Single-Molecule Sensing on Optical Microcavities[J]. ACS NANO,2024:13. |
| APA | Toropov, Nikita A.,Houghton, Matthew C.,Yu, Deshui,&Vollmer, Frank.(2024).Thermo-Optoplasmonic Single-Molecule Sensing on Optical Microcavities.ACS NANO,13. |
| MLA | Toropov, Nikita A.,et al."Thermo-Optoplasmonic Single-Molecule Sensing on Optical Microcavities".ACS NANO (2024):13. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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